Josh van der Flier is set to win his 50th cap on Saturday. He lines out in an unchanged back row as Caelan Doris is named to start alongside him and Peter O’Mahony.
In the front row, Dan Sheehan has been passed fit and will start with Andrew Porter and Tadhg Furlong on either side of the scrum in an all-Leinster front row.
The second row sees Ryan Baird joining James Ryan, as seven of the Ireland pack are made up of Leinster players.
Captain Johnny Sexton will be partnered at half-back by Jamison Gibson Park and Robbie Henshaw comes into the centre to play alongside Bundee Aki. The back three of Hugo Keenan, Mack Hansen and James Lowe start for a fifth consecutive Six Nations fixture.
Sexton equalled Ronan O’Gara’s Six Nations Championship all-time points scorer record (557 points) against Scotland and can become the outright top points scorer against England this weekend.
Jimmy O’Brien come into the match day 23 to join Cian Healy, Tom O’Toole, Jack Conan, Conor Murray and Ross Byrne who all featured last weekend in Murrayfield.
Ireland’s final game of the Championship will be broadcast live on VIRGIN and ITV television and RTE and BBCNI radio.
Ireland team to play England
15. Hugo Keenan (Leinster/UCD) 29 caps
14. Mack Hansen (Connacht/Corinthians) 13 caps
13. Robbie Henshaw (Leinster/Buccaneers) 61 caps
12. Bundee Aki (Connacht/Galwegians) 45 caps
11. James Lowe (Leinster) 19 caps
10. Johnny Sexton (Leinster/St Mary’s College) 112 caps (c)
9. Jamison Gibson Park (Leinster) 24 caps
1. Andrew Porter (Leinster/UCD) 52 caps
2. Dan Sheehan (Leinster/Lansdowne) 16 caps
3. Tadhg Furlong (Leinster/Clontarf) 64 caps
4. Ryan Baird (Leinster/Dublin University) 10 caps
5. James Ryan (Leinster/UCD) 52 caps
6. Peter O’Mahony (Munster/Cork Constitution) 93 caps
7. Josh van der Flier (Leinster/UCD) 49 caps
8. Caelan Doris (Leinster/St Mary’s College) 27 caps
16. Rob Herring (Ulster/Ballynahinch) 33 caps
17. Cian Healy (Leinster/Clontarf) 122 caps
18. Tom O’Toole (Ulster/Ballynahinch) 8 caps
19. Kieran Treadwell (Ulster/Ballymena) 10 caps
20. Jack Conan (Leinster/Old Belvedere) 37 caps
21. Conor Murray (Munster/Garryowen) 104 caps
22. Ross Byrne (Leinster/UCD) 18 caps
23. Jimmy O’Brien (Leinster/Naas) 4 caps