There are four changes to the side that started against New Zealand last Saturday.

Garry Ringrose and Paddy Jackson start in place of the injured Robbie Henshaw and Johnny Sexton while Keith Earls comes onto the left wing and Iain Henderson starts in the second row.

Rory Best will win his 100th cap as he leads the team out on Saturday – becoming only the fifth Irish player to reach the century milestone. Brian O’Driscoll (133), Ronan O’Gara (128), Paul O’Connell (108) and John Hayes (105) are the other players to reach 100 caps.

He is joined in the front row by Jack McGrath and Tadhg Furlong while Henderson partners Devin Toner in the second row.

The back row of CJ Stander, Sean O’Brien and Jamie Heaslip start again this week.

Conor Murray will partner Jackson in the half-backs with Ringrose joining Jared Payne in the centre.

Keith Earls comes in on the left wing with Andrew Trimble on the right and Rob Kearney at full-back.

Joey Carbery and Ultan Dillane come back in to the replacements with Simon Zebo also moving to the bench. Sean Cronin, Cian Healy, Finlay Bealham, Josh van der Flier and Kieran Marmion complete the squad.

Ireland Team & Replacements (v Australia, Guinness Series 2016, Aviva Stadium, Saturday, November 26, 5.30pm)

15. Rob Kearney (UCD/Leinster) 71
14. Andrew Trimble (Ballymena/Ulster) 68
13. Jared Payne (Ulster) 18
12. Garry Ringrose (UCD/Leinster) 2
11. Keith Earls (Young Munster/Munster) 53
10. Paddy Jackson (Dungannon/Ulster) 18
9. Conor Murray (Garryowen/Munster) 52
1. Jack McGrath (St. Mary’s College/Leinster) 35
2. Rory Best (Banbridge/Ulster) 99 (Captain)
3. Tadhg Furlong (Clontarf/Leinster) 10
4. Iain Henderson (Ballynahinch/Ulster) 27
5. Devin Toner (Lansdowne/Leinster) 41
6. CJ Stander (Munster) 9
7. Sean O’Brien (UCD/Leinster) 44
8. Jamie Heaslip (Dublin University/Leinster) 90 (Vice Captain)

Replacements

16. Sean Cronin (St Mary’s College/Leinster) 55
17. Cian Healy (Clontarf/Leinster) 61
18. Finlay Bealham (Buccaneers/Connacht) 5
19. Ultan Dillane (Galway Corinthians/Connacht) 7
20. Josh van der Flier (UCD/Leinster) 4
21. Kieran Marmion (Galway Corinthians/Connacht) 8
22. Joey Carbery (Clontarf/Leinster) 2
23. Simon Zebo (Cork Constitution/Munster) 27